This conference takes place nearly five years after the Declaration of Astana and will focus on advancing Primary Health Care (PHC) in developed and developing countries as a priority for national health security and securing the health of people around the world. The 2021 U.S. National Academies’ report, Implementing High Quality Primary Care led to the creation of a primary care strategy coordinating infrastructure within the US Federal Government (USG) that promises to build toward primary health care as a common good and as a solution to national health priorities. This new infrastructure also seeks to promote collaboration that will both strengthen primary care (PC) in the United States as well as primary health care around the world. It is supported by a national, external advisory function of the National Academies of Sciences, Engineering, and Medicine. While this US infrastructure may be a model for other countries, many nations are already ahead of the US in implementing fit-for-purpose primary health care, encouraging partnerships with public health, promoting global health security, and improving health equity.